Prionex® – Protein stabilizer by Pentapharm

Due to the chemical nature and the standardised quality, Prionex® can be used as an inert protein stabilizer and as an additive for cell culture media.

Prionex® Application

Prionex® is a 10% aqueous solution of a polypeptide fraction of highly purified dermal collagen of porcine origin which has excellent protein stabilizing properties. Prionex® is prepared by partial hydrolysis and is terminally sterilized. It is free from cartilage, bone and plasma components and is therefore a pure form of partially hydrolyzed gelatine type A.

Prionex® is a porcine collagen peptide fraction that has multiple advantages

Optimizes stability of biological activity
Improves conditions for lyophilisation and heat treatment
Avoids denaturation by chaotropic agents or solvents
Extends shelf life for enzymes and proteins
High consistency stabilizer
Non-toxic and non-antigenic
Free from nucleic acids, polysaccharides and lipids
Free from any additives

MW

The average molecular weight is approx. 20’000 Da, estimated by gel permeation chromatography.

Solubility

Prionex® is freely soluble in water, diluted electrolyte solutions, glycerol and DMSO as well as in diluted ethanol and ammonium sulphate solutions below 20% saturation. Storage: 15 – 25°C, protected from light

References

Gaffney PJ, Edgell TA, Dawson PA, Ford AW, Stocker K. A pig collagen peptide fraction. A unique material for maintaining biological activity during lyophilization and during storage in the liquid state. J Pharm Pharmacol 1996; 48: 896-8.

Prionex® Data Sheet

Prionex Poster